晁彥傑

發布部門🔁：沐鸣2平台 發布時間🚵🏿‍♂️🥉：2024-11-28

                        


個人簡介

晁彥傑博士🧑‍🎄，任中國科沐鸣2上海免疫與感染研究所研究員、感染與核酸功能研究室主任、微生物RNA系統生物學研究組組長🦃🚴🏽‍♂️、博士生導師🧑🏿‍🚒，現主持承擔國家重點研發計劃國際合作項目、國家重點研發計劃十四五項目子課題🕵🏽👩🏽、國家自然科學基金面上項目➔、中科院國合局重點項目👩🏿‍🦱👸🏼、上海市自然科學基金等多10余個科研項目👩🏻‍🦰。在Nature, Molecular Cell, Nature Comms, EMBO J, EMBO Mol Medicine, Emerging Microbes & Infections, Trends in Microbiology等雜誌發表30篇高影響力論文，受到Nature等雜誌點評和F1000專家推薦🧝🏼‍♂️，累計引用超過7000次🈳。兼任EMBO J、NAR、mBio等30多家領域權威期刊的審稿專家和BMC Genomics等多家雜誌編委，上海微生物學會基礎微生物專業委員會委員，中國生物化學與分子生物學會永久會員。


研究方向

  1. 病原生物學與感染

  2. 非編碼RNA與基因調控機製

  3. 新型疫苗研發


主持與承擔主要項目情況

1.  國家重點研發計劃政府間合作項目：病原細菌無帽小RNA 調控功能的系統研究🧖🏼‍♂️，2022-2025，主持；

2.  國家重點研發計劃十四五項目：重要感染中病原-共生微生物-宿主互作和幹預🧑🏿‍🔧，2022-2025，子課題負責人☣️；

3.  國家自然科學基金面上項目：沙門菌小RNA CpxQ抑製鞭毛基因表達與細菌運動性的機製研究🌁，2023-2026🖖🏿，主持；

4.  中國科沐鸣2國際夥伴計劃-中日合作項目：病原細菌無帽小RNA的生成機製與功能研究👨‍👧，2023-2026，主持；

5.  上海市自然科學基金面上項目：沙門氏菌啟動PhoPQ通路與SPI-2胞內寄生機製的時序調控機理🎱，2021-2024，主持🧡；

6. 中國科沐鸣2B類戰略性先導科技專項：核糖核酸高效使能的基礎與應用研究🏣，2023-2028🧃，參與；

7. 上海市科技重大專項：腸道穩態的生命調控機理及藥物靶標結構與功能研究🙎🏿‍♂️，2019-2022，參與。


發表論著情況

  1. K Wu#, X Lin#, Y Lu#, R Dong, H Jiang, SL Svensson, J Zheng, N Shen, A Camilli, Y Chao*. (2024) RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor ofcapsular mucoviscosity and virulence. Nature Communications. In revision.

  2. J Zhang#, S Zhang#, W Zhou#, X Zhang#, G Li, L Li, X Lin, F Liu, Y Gao*, Z Chen*, Y Chao*, C Wang*. (2024) A widely conserved protein Rof inhibits transcription termination factor Rho and promotes Salmonella virulence program. Nature Communications. 15(1):3187.

  3. Y Chen, YX Goh, P Li, J Guan, Y Chao, H Qu*, HY Ou*, X Wang*. (2024). RES-Xre toxin-antitoxin locus knaAT maintains the stability of the virulence plasmid in Klebsiella pneumoniae.Emerging Microbes & Infections.13(1):2316814.

  4. J Li#, Z Chen#, Q Wang, L Du, Y Yang, F Guo, X Li, Y Chao, Y Ma*. (2024). Microbial and metabolic profiles unveil mutualistic microbe-microbe interaction in obesity-related colorectal cancer. Cell Reports Medicine. 5(3):101429

  5. F Liu#, Z Chen#, S Zhang, K Wu, C Bei, C Wang*, Y Chao*. (2023). In vivo RNA interactome profiling reveals 3’UTR-processed sRNA targeting a central regulatory hub. Nature Communications. 14(1):8106.

[Press coverage]

  1. Z Liu, J Guan, Z Chen, C Tai, Z Deng, Y Chao*, HY Ou*. (2023) CpxR promotes antibiotic resistance by activating plasmid-borne blaKPC expression and plasmid transfer in carbapenem-resistant Klebsiella pneumoniae. Emerging Microbes & Infections. 12(2):2256427

  2. Z Chen, W Jin, Y Chao*, Y Ma*. (2023) Decoding the microbiome: advances in genetic manipulation for gut bacteria. Trends in Microbiology. 31(11):1143-1161

  3. PK Grucela, F Tobias, S Uwe, Y Chao*, YE Zhang*. Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli. Microbial Cell. 10 (7), 141-144

  4. Jin WY, Guo JX, Zhang M, Teng LZ, Chao Y, Sansonetti PJ*, Gao YZ*. (2023)Absolute quantification of the microbiota spatial distribution in the murine large intestine.Innovation Life. 1(2):100030

  5. S Zhao, Q Xu, Y Cui, S Yao, S Jin, Q Zhang, Z Wen, H Ruan, X Liang, Y Chao, S Gong, P Sansonetti, K Wei*, H Tang*, Y Jiu*. (2023) Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection. Nature Communications. 14 (1), 478

  6. SL Svenson, Y Chao*. (2022) RNase III-CLASH brings bacterial RNA networks into focus. Trends in Microbiology. 30 (12):1125-1127

  7. Zhao Y, Yuan Z, Wang S, Wang H, Chao Y, Sederoff RR, Sederoff H, Yan H, Pan J, Peng M, Wu D, Borriss R, Niu B*. (2022) Gene sdaB Is Involved in the Nematocidal Activity of Enterobacter ludwigii AA4 Against the Pine Wood Nematode Bursaphelenchus xylophilus. Front Microbiol. 13:870519.

  8. Dong X#, Chao Y#, Zhou Y, Zhou R, Zhang W, Fischetti VA, Wang X, Feng Y*, Li J*. (2021) The global emergence of a novel Streptococcus suis clade associated with human infections. EMBO Mol Medicine. 13(7):e13810.

[Highlighted by Nature]

  1. Islam MS, Bandyra KJ, Chao Y, Vogel J, Luisi BF*. (2021) RNase E endonuclease activity and its inhibition by pseudouridine. RNA. 27(11):1339-1352.

  2. Li L, Chao Y*. (2020) sPepFinder expedites genome-wide identification of small proteins in bacteria. BioRxiv. doi: 10.1101/2020.05.05.079178.

  3. Wang C*, Chao Y, Matera G, Gao Q, Vogel J*. (2020) The conserved 3′ UTR-derived small RNA NarS mediates mRNA crossregulation during nitrate respiration. Nucleic Acids Research. 48 (4), 2126-2143.

  4. Li L, Förstner KU, Chao Y*. (2018) Computational analysis of RNA-protein interactions via deep sequencing. Methods in Molecular Biology. 1751:171-182.

  5. Chao Y, Li L, Girodat D, Förstner KU, Said N, Corcoran C, Smiga M, Papenfort K, Reinhardt R, Wieden HJ, Luisi BF, Vogel J*. (2017) In vivo cleavage map illuminates the central role of RNase E in coding and non-coding RNA pathways. Molecular Cell. 65(1):39-51.

[Previewed in Mol Cell] [Recommendation by F1000prime]

  1. Chao Y, Vogel J*. (2016) A 3’ UTR-derived small RNA provides the regulatory noncoding arm of the inner membrane stress response. Molecular Cell. 61(3):352-63.

  2. Westermann AJ, Förstner KU, Amman F, Barquist L, Chao Y, Schulte LN, Müller L, Reinhardt R, Stadler PF, Vogel J*. (2016) Dual RNA-seq unveils noncoding RNA functions in host–pathogen interactions. Nature. 529(7587):496-501.

[Commentary in Nature] [Highlighted in Nat. Rev. Genet.][Recommendation by F1000] [Press coverage]

  1. Saadeh B, Caswell CC, Chao Y, Berta P, Wattam AR, Roop II M, O'Callaghan D*. (2016) Transcriptome-wide identification of Hfq-associated RNAs in Brucella suis by deep sequencing. J Bacteriol. 198(3):427-435.

  2. Fan B*, Li L#, Chao Y#, Förstner K, Vogel J, Borriss R, Wu XQ*. (2015) dRNA-seq reveals genomewide TSSs and noncoding RNAs of plant beneficial rhizobacterium Bacillus amyloliquefaciens FZB42. PLoS ONE. 10(11): e0142002.

  3. Miyakoshi M, Chao Y, Vogel J*. (2015) Cross talk between ABC transporter mRNAs via a target mRNA-derived sponge of the GcvB small RNA. EMBO J. 34:1478-1492.

[Previewed in EMBO J]

  1. Miyakoshi M, Chao Y, Vogel J*. (2015) Regulatory small RNAs from the 3' regions of bacterial mRNAs. Curr Opin Microbiol. 24:132-139.

  2. Caldelari I, Chao Y, Romby P*, Vogel J*. (2013) RNA-mediated regulation in pathogenic bacteria. Cold Spring Harb Perspect Med. 3:a010298.

  3. Papenfort K, Corcoran CP, Gupta SK, Miyakoshi M, Heidrich N, Chao Y, Fröhlich KS, Sharma CM, Ziebuhr W, Böhm A, and Vogel J*. (2013) Regulatory Mechanisms of Special Significance: Role of Small RNAs in Virulence Regulation. Regulation of Bacterial Virulence (eds. Vasil ML, Darwin AJ), ASM Press. pp: 493-527.

  4. Chao Y, Papenfort K, Reinhardt R, Sharma CM, Vogel J*. (2012) An atlas of Hfq-bound transcripts reveals 3' UTRs as a genomic reservoir of regulatory small RNAs. EMBO J. 31(20):4005-19.

[Previewed in EMBO J] [Multiple recommendations by F1000]

  1. Kröger C, Dillon SC, Cameron AD, Papenfort K, Sivasankaran SK, Hokamp K, Chao Y, Sittka A, Hébrard M, Händler K, Colgan A, Leekitcharoenphon P, Langridge GC,Lohan AJ, Loftus B, Lucchini S, Ussery DW, Dorman CJ, Thomson NR, Vogel J, Hinton JCD *. (2012) The transcriptional landscape and small RNAs of Salmonella enterica serovar Typhimurium. Proc Natl Acad Sci U S A. 109(20):E1277-86.

[Press coverage]

  1. Deltcheva E, Chylinski K#, Sharma CM#, Gonzales K, Chao Y, Pirzada ZA, Eckert MR, Vogel J, Charpentier E*. (2011) CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III. Nature. 471(7340):602-7.

[Previewed in Nature] [Multiple recommendations by F1000] [Press coverage][Kavli Prize Collection][2020 Nobel Prize in Chemistry]

  1. Chao Y, Vogel J*. (2010) The role of Hfq in bacterial pathogens. Curr Opin Microbiol. 13(1):24-33.

[Top 5 most cited articles in COM, 2011-2015]

  1. Sun Z#,*, Chao Y#, Zhang X, Zhang J, Li Y, Qiu Y, Liu Y, Nie L, Guo A, Li C*. (2008) Characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates in China. J Clin Microbiol. 46:4075-7.

  2. Chen Y#, Chao Y#, Deng Q#, Liu T, Xiang J, Chen J, Zhou J, Zhan Z, Kuang Y, Cai H, Chen H, Guo A*. (2009) Potential challenges to the Stop TB Plan for humans in China; cattle maintain M. bovis and M. tuberculosis. Tuberculosis (Edinb). 89:95-100.

  3. Yan BF#, Chao YJ#, Chen Z, Tian KG, Wang CB, Lin XM, Chen HC, Guo AZ*. (2008) Serological survey of bovine herpesvirus type 1 infection in China. Vet Microbiol.  127:136-41.

  4. Xu Z#,*, Chao Y#, Si Y, Wang J, Jin M, Guo A, Qian P, Zhou R, Chen H*. (2008) The GTP binding sites interacted with RNA-dependent RNA polymerase of classical swine fever virus in de novo initiation. In Silico Biol. 8(1):21-32.   

  5. Han H, Wang F, Xiao Y, Ren Y, Chao Y, Guo A, Ye L*. (2007) Utility of mycobacterial interspersed repetitive unit typing for differentiating Mycobacterium tuberculosis isolates in Wuhan, China. J Med Microbiol. 56:1219-23.  



聯系方式

Email🚶🏻‍♂️‍➡️👩🏿‍🚒：yjchao@siii.cas.cn 

辦公地址♥️：嶽陽路320號新生命大樓B711




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