張珂

個人簡介

張珂，博士🎃，中國科沐鸣2上海免疫與感染研究所研究員。2012年於中國科沐鸣2微生物研究所獲得博士學位，2013年至2021年於美國德克薩斯大學西南醫學中心進行博士後研究。目前發表SCI論文20余篇🛗。主持國家自然科學基金1項、國家自然科學基金專項項目2項。

研究方向

1. 病毒感染與RNA生物學

2. 抗病毒藥物研發

榮譽及獲獎情況

1. 上海市白玉蘭人才計劃—2023年

2. 上海市浦江人才—2022年

主持與承擔主要項目情況

1. 國家自然科學基金“A型流感病毒mRNA出核轉運分子機製的研究”，主持🚺；

2. 國家自然基金委專項“抗猴痘病毒miRNA藥物的篩選🍒、鑒定及機製研究”👨🏼‍🏭🏍，主持；

3. 國家自然基金委專項“新型冠狀病毒病抑製宿主mRNA出核轉運的分子機製研究”，主持；

發表論著情況

(1) Jiayin Guo, Yaru Zhu, Xiaoya Ma, Guijun Shang, Bo Liu* and Ke Zhang*. (2023) Virus Infection and mRNA Nuclear Export. Int. J. Mol. Sci. 24(16): 12593. (Co-Corresponding Author)

(2) Pengtao Jiao, Wenhui Fan, Xiaoya Ma, Runshan Lina, Yuna Zhao, Yabo Li, He Zhang, Xiaojuan Jia, Yuhai Bi, Xiaoli Feng, Minghua Li, Wenjun Liu, Ke Zhang*, and Lei Sun*. (2023) SARS-CoV-2 nonstructural protein 6 triggers endoplasmic reticulum stress-induced autophagy to degrade STING1. Autophagy. https://doi.org/ 10.1080/15548627.2023.2238579. (Co-Corresponding Author)

(3) Ke Zhang, Lisa Miorin, Tadashi Makio, Ishmael Dehghan, Shengyan Gao, Yihu Xie, Hualin Zhong, Matthew Esparza, Boning Gao, John D. Minna, Zhijian Chen, Adolfo García-Sastre, Yi Ren, Richard W. Wozniak, Beatriz M.A. Fontoura. (2021) Nsp1 Protein of SARS-CoV-2 Disrupts the mRNA Export Machinery to Inhibit Host Gene Expression. Science Advances 7(6):eabe7386.

(4) Lisa Miorin, Thomas Kehrer, Maria Teresa Sanchez-Aparicio, Ke Zhang, Phillip Cohen, Roosheel S Patel, Anastasija Cupic, Tadashi Makio, Menghan Mei, Oded Danziger, Elena Moreno, Kris M White, Raveen Rathnasinghe, Melissa Uccellini, Shengyan Gao, Teresa Aydillo-Gomez, Ignacio Mena, Xin Yin, Laura Martin-Sancho, Nevan J Krogan, Sumit K Chanda, Michael Schotsaert, Richard W Wozniak, Yi Ren, Brad R Rosenberg, Beatriz M A Fontoura, Adolfo García-Sastre. (2020) SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling. Proc. Natl. Acad. Sci. 117(45):28344-28354.

(5) Ke Zhang#, Yihu Xie#, Raquel Muñoz-Moreno, Juan Wang, Liang Zhang, Matthew Esparza, Adolfo García-Sastre, Beatriz M.A. Fontoura, Yi Ren. (2019) Structural Basis for Influenza Virus NS1 Protein Block of mRNA Nuclear Export. Nature Microbiology. 4(10):1671-1679. (Co-First Author)

(6) Ke Zhang, Guijun Shang, Abhilash Padavannil, Juan Wang, Ramanavelan Sakthivel, Xiang Chen, Min Kim, Matthew G Thompson, Adolfo García-Sastre, Kristen W Lynch, Zhijian J Chen, Yuh Min Chook, Beatriz MA Fontoura. (2018) Structural–functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proc. Natl. Acad. Sci. 115(52):E12218-E12227.

(7) Ke Zhang#, Zhao Wang#, Guizhang Fan, Juan Wang, Shengyan Gao, Yun Li, Lei Sun, Changcheng Yin, Wenjun Liu. (2015) Two polar residues within C- terminal domain of M1 are critical for the formation of influenza A Virions. Cellular Microbiology 17(11): 1583-93. (Co-First Author)

(8) Ke Zhang, Zhao Wang, Xiaoling Liu, Changcheng Yin, Zeshan Basit, Bin Xia, Wenjun Liu. (2012) Dissection of Influenza A Virus M1 Protein: pH-Dependent oligomerization of N-Terminal Domain and Dimerization of C-Terminal Domain. PLoS ONE 7(5): e37786.

聯系方式

Email🧑‍🦰：kzhang6@siii.cas.cn 

辦公地址😅：上海市徐匯區嶽陽路320號新生命科學大樓B705