史向陽

個人簡介

史向陽，博士生導師🕝，校特聘教授🫷🏿。1998年於中科院感光化學研究所獲博士學位。2008年回國前，在美國密歇根大學歷任博士後研究員、第二級副研究員、研究員和研究助理教授。主要學術兼職包括：葡萄牙馬德拉大學“邀請納米技術主任”；WIREs Nanomed. Nanobiotechnol.期刊副主編；Bioconjugate Chem.🧑‍💻、Nanomedicine、Pharmaceutics等期刊編委。北京生理科學會常務理事、上海市生物物理學會理事。

研究方向

基於樹狀大分子及其它類高分子的納米醫學、生物材料研究🥬，主攻方向為腫瘤和炎症（包括肺炎、關節炎𓀛、腦卒中🧑🏽‍🚀、帕金森等）診療和預防的納米藥物基礎及應用基礎研究。

榮譽及獲獎情況

2008/2013年獲上海高校特聘教授（東方學者）及跟蹤計劃，2011年教育部新世紀優秀人才🚼，2018年上海市領軍人才，2019年上海市優秀學術帶頭人🥶。2014年獲第五屆中國僑界貢獻獎創新人才獎；2016年獲華夏醫學科技獎二等獎；2017年獲上海市科技進步獎一等獎😴；2018年獲上海市自然科學獎一等獎。2019-2021愛思維爾中國高被引學者👰🏿🚙，2019 年英國皇家化學會Top 1% 高被引中國作者。

主持與承擔主要項目情況

主持項目包括科技部國家重點研發計劃國合專項1項；國家自然基金重點國合項目1項🪘、中德中心項目2項👨‍🦯🤦🏻‍♀️、面上項目3項↕️、一般國際交流項目1項及上海市科委/教委項目多項。

發表論著情況

發表SCI收錄期刊論文457篇👨🏽‍🎨，論文引用超過23000次，H-index為79。

主要學術論文（2017-2022代表作）

1.     Tingting Xiao^#, Jianzhi Zhu^#, Liang Jia^#, Hailong Che, Jie Liu, N. Amy Yewdall, J. Deckers, and Jan C. M. van Hest*, Xiangyang Shi*. Injectable alginate hydrogels for synergistic tumor combination therapy via repolarization of TAMs. J. Controlled Release2022, 348, 239-249.

2.     Jin Li, Liang Chen, Changsheng Li, Yu Fan, Mengsi Zhan, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, Xiangyang Shi*. Phosphorus Dendron Nanomicelles as a Platform for Combination Anti-Inflammatory and Antioxidative Therapy of Acute Lung Injury. Theranostics2022, 12(7), 3407-3419.

3.     Changchang Zhang^#, Wenzhi Tu^#, Xuming Chen, Bing Xu, Xin Li, Chaolei Hu, Mingwu Shen, Shaoli Song, Chunjuan Jiang, Shengyu Yao, Andrij Pich*, Yong Liu*, Xiangyang Shi*. Intelligent design of polymer nanogels for full-process sensitized radiotherapy and dual-mode computed tomography/magnetic resonance imaging of tumors. Theranostics2022, 12(7): 3420-3437.

4.     Zhiqiang Wang, Yunqi Guo, Yu Fan, Jingwen Chen, Han Wang, Mingwu Shen, Xiangyang Shi*. Metal-Phenolic Network-Coated Dendrimer-Drug Conjugates for Tumor MR Imaging and Chemo/Chemodynamic Therapy via Amplification of Endoplasmic Reticulum Stress. Adv. Mater.2022, 34, 2107009.

5.     Yao Xu, Yunqi Guo, Changchang Zhang, Mengsi Zhan, Liang Jia, Shaoli Song, Chunjuan Jiang, Mingwu Shen, Xiangyang Shi*. Fibronectin-Coated Metal-Phenolic Networks as a Platform for Cooperative Tumor Chemo/Chemodynamic/Immune Therapy via Enhanced Ferroptosis-Mediated Immunogenic Cell Death. ACS Nano2022, 16, 984-996.

6.     Yingchao Hao, Yue Gao, Yu Fan, Changchang Zhang, Mengsi Zhan, Xueyan Cao, Xiangyang Shi*, Rui Guo*. A Tumor Microenvironment-Responsive Poly(amidoamine) Dendrimer Nanoplatform for Hypoxia-Responsive Chemo/Chemodynamic Therapy. J. Nanobiotechnol.2022, 20, 43.

7.     Jingchao Li^#, Xiangrong Yu^#, Xiangyang Shi,* Mingwu Shen*. Cancer nanomedicine based on polyethylenimine-mediated multifunctional nanosystems. Prog. Mater. Sci.2022, 124, 100871.

8.     Wei Hu, Tingting Xiao, Du Li, Yu Fan, Lingxi Xing*, Xipeng Wang, Yulin Li*, Xiangyang Shi*, Mingwu Shen*. Intelligent Molybdenum Disulfide Complexes as a Platform for Cooperative Imaging-Guided Tri-mode Chemo-Photothermo-Immunotherapy. Adv. Sci.2021, 8, 2100165.

9.     Xin Li, Haitao Sun, Helin Li, Chaolei Hu, Yu Luo*, Xiangyang Shi* and Andrij Pich*. Multi-responsive biodegradable cationic nanogels for highly efficient treatment of tumors. Adv. Funct. Mater.2021, 31, 2100227.

10.  Xin Li^#, Helin Li^#, Changchang Zhang, Andrij Pich*, Lingxi Xing*, and Xiangyang Shi*. Intelligent nanogels with self-adaptive responsiveness for improved tumor drug delivery and augmented chemotherapy. Bioact. Mater. 2021, 6, 3473-3484.

11.  Xin Li, Zhijun Ouyang, Helin Li, Chaolei Hu, Pabitra Saha, Lingxi Xing*, Xiangyang Shi*, Andrij Pich*. Dendrimer-decorated nanogels: Efficient nanocarriers for biodistribution in vivo and chemotherapy of ovarian carcinoma. Bioact. Mater. 2021, 6, 3244-3253.

12.  Dan Li, Lizhou Lin, Yu Fan, Long Liu, Mingwu Shen, Rong Wu, Lianfang Du*, Xiangyang Shi*. Ultrasound-Enhanced Fluorescence Imaging and Chemotherapy of Multidrug-Resistant Tumors Using Multifunctional Dendrimer/Carbon Dot Nanohybrids. Bioact. Mater.2021, 6, 729-739.

13.  Tingting Xiao, Meijuan He, Fang Xu, Yu Fan, Bingyang Jia, Mingwu Shen, Han Wang* and Xiangyang Shi*. Macrophage Membrane-Camouflaged Responsive Polymer Nanogels Enable Magnetic Resonance Imaging-Guided Chemotherapy/Chemodynamic Therapy of Orthotopic Glioma. ACS Nano2021, 15, 20377–20390.

14.  Liang Jia, Xin Li, Hui Liu, Jindong Xia, Xiangyang Shi*, Mingwu Shen*. Ultrasound-enhanced precision tumor theranostics using cell membrane-coated and pH-responsive nanoclusters assembled from ultrasmall iron oxide nanoparticles. Nano Today2021, 36, 101022.

15.  Yunchao Xiao^#, Yu Fan^#, Wenzhi Tu, Shiyi Lu, Yupei Ma, Yuesheng Ning, Yong Liu*, and Xiangyang Shi*. Multifunctional PLGA Microfibrous Rings Enable MR Imaging-Guided Tumor Chemotherapy and Metastasis Inhibition Through Prevention of Circulating Tumor Cell Shedding. Nano Today2021, 38, 101123.

16.  Cong Song, Zhijun Ouyang, Yue Gao, Honghua Guo, Shunjuan Wang, Dayuan Wang, Jindong Xia, Mingwu Shen,* Xiangyang Shi*. Modular Design of Multifunctional Core-Shell Tecto Dendrimers Complexed with Copper(II) for MR Imaging-Guided Chemodynamic Therapy of Orthotopic Glioma. Nano Today2021, 41, 101325.

17.  Chao Yang, Yue Gao, Yu Fan, Liu Cao, Jin Li, Yulong Ge, Wenzhi Tu, Yong Liu, Xueyan Cao, and Xiangyang Shi*. Dual-mode endogenous and exogenous sensitization of tumor radiotherapy through antifouling dendrimer-entrapped gold nanoparticles. Theranostics2021, 11(4), 1721-1731.

18.  Zhijuan Xiong, Yue Wang, Wei Zhu, Zhijun Ouyang, Yu Zhu, Mingwu Shen, Jindong Xia*, Xiangyang Shi*. A Dual-Responsive Platform Based on Antifouling Dendrimer-CuS Nanohybrids for Enhanced Tumor Delivery and Combination Therapy. Small Methods2021, 5, 2100204.

19.  Tingting Xiao, Wei Hu, Yu Fan, Mingwu Shen, Xiangyang Shi*. Macrophage-Mediated Tumor Homing of Hyaluronic Acid Nanogels Loaded with Polypyrrole and Anticancer Drug for Targeted Combinational Photothermo-Chemotherapy. Theranostics2021, 11(14), 7057-7071. doi: 10.7150/thno.60427.

20.  Jin Li, Liang Chen, Xiaoying Xu, Yu Fan, Xue Xue, Mingwu Shen*, Xiangyang Shi*. Targeted Combination of Antioxidative and Anti-Inflammatory Therapy of Rheumatoid Arthritis Using Multifunctional Dendrimer-Entrapped Gold Nanoparticles as a Platform. Small2020, 16, 2005661.

21.  Jianzhi Zhu^#, Tingting Xiao^#, Yuxin Shi, Hailong Che, Xiangyang Shi* and Jan C. M. Hest*. Surface charge switchable nanoclusters for MRI-guided synergistic photodynamic therapy. ACS Nano2020, 14, 11225-11237.

22.  Yu Fan, Lizhou Lin, Fangfang Yin, Yu Zhu, Han Wang, Lianfang Du, Serge Mignani, Jean-Pierre Majoral*, Xiangyang Shi*. Phosphorus Dendrimer-Based Copper(II) Complexes Enable Ultrasound-Enhanced Tumor Theranostics. Nano Today2020, 33, 100899.

23.  Cong Song, Mingwu Shen, João Rodrigues, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*.Superstructured poly(amidoamine) dendrimer-based nanoconstructs as platforms for cancer nanomedicine: a concise review. Coord. Chem. Rev.2020, 421, 213463.

24.  Lingxi Xing^#, Xin Li^#, Zehua Xing^#, Fan Li, Mingwu Shen, Hong Wang*, Xiangyang Shi*, Lianfang Du*. Silica/Gold Nanoplatform combined with a Thermosensitive Gel for Imaging-guided Interventional Therapy in PDX of Pancreatic Cancer. Chem. Eng. J.2020, 382, 122949.

25.  Fang Xu^#, Jianzhi Zhu^#, Lizhou Lin^#, Changchang Zhang, Wenjie Sun, Yu Fan, Fangfang Yin, Jan C. M. van Hest, Han Wang, Lianfang Du* and Xiangyang Shi*. Redox-responsive PVCL nanogels loaded with MnO₂ nanoparticles and doxorubicin for imaging-guided and UTMD-promoted chemotherapy of tumors. Theranostics2020, 10(10), 4349-4358.

26.  Yu Fan^#, Wenzhi Tu^#, Mingwu Shen, Xuming Chen, Yuesheng Ning, Junjun Li, Tingfeng Chen, Han Wang, Fangfang Yin, Yong Liu*, Xiangyang Shi*. Targeted Tumor Hypoxia Dual Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer-Based Nanosensitizers. Adv. Funct. Mater.2020, 30, 1909285.

27.  Xin Li^#, Shiyi Lu^#, Zuogang Xiong, Yong Hu, Dan Ma, Wenqi Lou, Chen Peng*, Mingwu Shen*, Xiangyang Shi*. Light-Addressable Nanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and Dynamic Magnetic Resonance Imaging of Arthritis. Adv. Sci.2019, 6, 1901800.

28.  Chao Cai, Xin Li, Yue Wang, Mengxue Liu, Xiangyang Shi*, Jindong Xia*, Mingwu Shen*. Polydopamine-Coated Gold Core/Hollow Mesoporous Silica Shell Particles as a Nanoplatform for Multimode Imaging and Photothermal Therapy of Tumors. Chem. Eng. J.2019, 362, 842-850.

29.  Yu Fan, Jiulong Zhang, Menghan Shi, Dan Li, Chunhua Lu, Xueyan Cao, Chen Peng*, Serge Mignani*, Jean-Pierre Majoral*, Xiangyang Shi*. PAMAM Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for Radiotherapy-Enhanced MR Imaging and Chemotherapy of Tumors and Tumor Metastasis. Nano Lett.2019, 19, 1216−1226.

30.  Jianzhi Zhu^#, Zhicong Li^#, Changchang Zhang, Lizhou Lin, Shoupeng Cao, Hailong Che, Xiangyang Shi*, Han Wang*, Jan C. M. van Hest*. Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy. Theranostics2019, 9(26), 8048-8060.

31.  Shiyi Lu, Xin Li, Jiulong Zhang, Chen Peng,* Mingwu Shen,* and Xiangyang Shi*. Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging-Guided Combination Therapy of Tumors. Adv. Sci.2018, 5, 1801612.

32.  Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, and Xiangyang Shi*. Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem. Soc. Rev.2018, 47, 1874-1900.

33.  Lizhou Lin^#, Yu Fan^#, Feng Gao, Lifang Jin, Dan Li, Wenjie Sun,Fan Li, Peng Qin, Qiusheng Shi*, Xiangyang Shi*, Lianfang Du*.UTMD-Promoted Co-Delivery of Gemcitabine and miR-21 Inhibitor by Dendrimer-Entrapped Gold Nanoparticles for Pancreatic Cancer Therapy. Theranostics2018, 8(7), 1923-1939.

34.  Yu Fan^#, Wenjie Sun^#, Xiangyang Shi*. Design and Biomedical Applications of Poly(amidoamine) Dendrimer-Based Hybrid Nanoarchitectures. Small Methods2017, 1(12), 1700224.

其他信息

國際交流與合作：美國密歇根大學、法國國家科研中心配合物化學實驗室、法國巴黎大學、法國波爾多大學、德國亞琛工業大學/萊布尼茨聚合物研究所、荷蘭埃因霍溫理工大學🗡、葡萄牙馬德拉大學、匈牙利徳布勒森大學、日本大阪大學、韓國檀國大學🧏‍♀️、以色列巴伊蘭大學、波蘭羅茨大學👨🏻‍🦯、土耳其海峽大學💔、白俄羅斯國家科沐鸣2生物物理與細胞工程研究所。

主講課程：

博士研究生課程🟤：先進納米醫學和博士生Seminar✪☎；本科生課程：納米醫學。

博士後和研究生招生信息：

歡迎感興趣的具有化學、化工、生物醫學、材料、紡織等相關研究背景的博士生申請博士後研究職位，同時歡迎感興趣的具有相同背景的本科生和碩士生報考加入本課題組🦼🌪。

聯系方式

E-mail: xshi@dhu.edu.cn